Names & Taxonomy

Uniprot ID:
P29275
Entry Name:
AA2BR_HUMAN
Status:
reviewed
Protein Names:
Adenosine receptor A2b
Gene Names:
ADORA2B
Gene Names Primary:
ADORA2B
Organism:
Homo sapiens (Human)

Structure

Length:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Cross Reference Drug Bank:
DB00640 DB04932 DB00824 DB00277
Gene Ontology Go:
integral component of plasma membrane
intracellular
plasma membrane
G-protein coupled adenosine receptor activity
activation of adenylate cyclase activity
activation of MAPK activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular defense response
cellular protein metabolic process
cellular response to extracellular stimulus
excretion
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of chemokine production
positive regulation of chronic inflammatory response to non-antigenic stimulus
positive regulation of guanylate cyclase activity
positive regulation of interleukin-6 production
positive regulation of mast cell degranulation
positive regulation of vascular endothelial growth factor production
relaxation of vascular smooth muscle
Gene Ontology Biological Process:
activation of adenylate cyclase activity
activation of MAPK activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular defense response
cellular protein metabolic process
cellular response to extracellular stimulus
excretion
G-protein coupled receptor signaling pathway
JNK cascade
positive regulation of chemokine production
positive regulation of chronic inflammatory response to non-antigenic stimulus
positive regulation of guanylate cyclase activity
positive regulation of interleukin-6 production
positive regulation of mast cell degranulation
positive regulation of vascular endothelial growth factor production
relaxation of vascular smooth muscle
Gene Ontology Molecular Function:
G-protein coupled adenosine receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
intracellular
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1325798 7558011 15489334