Names & Taxonomy

Uniprot ID:
P29274
Entry Name:
AA2AR_HUMAN
Status:
reviewed
Protein Names:
Adenosine receptor A2a
Gene Names:
ADORA2A ADORA2
Gene Names Primary:
ADORA2A
Organism:
Homo sapiens (Human)

Structure

Length:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Cross Reference Drug Bank:
DB00640 DB00201 DB04932 DB00651 DB00824 DB00358 DB01303 DB00806 DB06213 DB01412 DB00277
Gene Ontology Go:
integral component of plasma membrane
membrane
plasma membrane
enzyme binding
G-protein coupled adenosine receptor activity
identical protein binding
activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
apoptotic process
blood circulation
blood coagulation
cAMP biosynthetic process
cell-cell signaling
cellular defense response
cellular protein metabolic process
central nervous system development
inflammatory response
neurotrophin TRK receptor signaling pathway
phagocytosis
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
sensory perception
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
apoptotic process
blood circulation
blood coagulation
cAMP biosynthetic process
cell-cell signaling
cellular defense response
cellular protein metabolic process
central nervous system development
inflammatory response
neurotrophin TRK receptor signaling pathway
phagocytosis
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
sensory perception
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
enzyme binding
G-protein coupled adenosine receptor activity
identical protein binding
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
plasma membrane
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
Itself; P30542; P62158; Q99418; P14416; P31424-1; Q7Z6G3; Q13107

Publication

PubMed ID:
1331670 8670304 15461802 14702039 15489334 20836733 7775460 16339847 18832607 10391209