Names & Taxonomy
- Uniprot ID:
- P29274
- Entry Name:
- AA2AR_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine receptor A2a
- Gene Names:
- ADORA2A ADORA2
- Gene Names Primary:
- ADORA2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 412
- Sequence:
- MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Cross Reference Drug Bank:
- DB00640 DB00201 DB04932 DB00651 DB00824 DB00358 DB01303 DB00806 DB06213 DB01412 DB00277
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
enzyme binding
G-protein coupled adenosine receptor activity
identical protein binding
activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
apoptotic process
blood circulation
blood coagulation
cAMP biosynthetic process
cell-cell signaling
cellular defense response
cellular protein metabolic process
central nervous system development
inflammatory response
neurotrophin TRK receptor signaling pathway
phagocytosis
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
sensory perception
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
apoptotic process
blood circulation
blood coagulation
cAMP biosynthetic process
cell-cell signaling
cellular defense response
cellular protein metabolic process
central nervous system development
inflammatory response
neurotrophin TRK receptor signaling pathway
phagocytosis
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
sensory perception
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- enzyme binding
G-protein coupled adenosine receptor activity
identical protein binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Itself; P30542; P62158; Q99418; P14416; P31424-1; Q7Z6G3; Q13107