Names & Taxonomy
- Uniprot ID:
- P29120
- Entry Name:
- NEC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1)
- Gene Names:
- PCSK1 NEC1
- Gene Names Primary:
- PCSK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 753
- Sequence:
- MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Function
- Function:
- Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
- Catalytic Activity:
- Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 167 167 Charge relay system.
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- extracellular space
secretory granule lumen
transport vesicle
serine-type endopeptidase activity
cell-cell signaling
cellular protein metabolic process
metabolic process
peptide biosynthetic process
peptide hormone processing
protein processing
proteolysis
regulation of insulin secretion - Gene Ontology Biological Process:
- cell-cell signaling
cellular protein metabolic process
metabolic process
peptide biosynthetic process
peptide hormone processing
protein processing
proteolysis
regulation of insulin secretion - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
- Gene Ontology Cellular Component:
- extracellular space
secretory granule lumen
transport vesicle - Keywords:
- Alternative splicing
Calcium
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Obesity
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Zymogen