Names & Taxonomy
- Uniprot ID:
- P28908
- Entry Name:
- TNR8_HUMAN
- Status:
- reviewed
- Protein Names:
- Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
- Gene Names:
- TNFRSF8 CD30 D1S166E
- Gene Names Primary:
- TNFRSF8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 595
- Sequence:
- MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKLHLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYLESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGLAGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm.
Function
- Function:
- Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
- Cross Reference Drug Bank:
- DB08870
- Gene Ontology Go:
- cytoplasm
extracellular exosome
integral component of plasma membrane
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
apoptotic signaling pathway
cellular response to mechanical stimulus
immune response
inflammatory response
multicellular organism development
negative regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of TRAIL biosynthetic process
positive regulation of tumor necrosis factor biosynthetic process
response to lipopolysaccharide
signal transduction
tumor necrosis factor-mediated signaling pathway - Gene Ontology Biological Process:
- apoptotic signaling pathway
cellular response to mechanical stimulus
immune response
inflammatory response
multicellular organism development
negative regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of TRAIL biosynthetic process
positive regulation of tumor necrosis factor biosynthetic process
response to lipopolysaccharide
signal transduction
tumor necrosis factor-mediated signaling pathway - Gene Ontology Molecular Function:
- transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
integral component of plasma membrane - Keywords:
- 3D-structure
Alternative initiation
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix