Names & Taxonomy
- Uniprot ID:
- P28907
- Entry Name:
- CD38_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)
- Gene Names:
- CD38
- Gene Names Primary:
- CD38
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 300
- Sequence:
- MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type II membrane protein.
Function
- Function:
- Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
- Catalytic Activity:
- NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
- Enzyme Regulation:
- ENZYME REGULATION: ATP inhibits the hydrolyzing activity.
- Active Site:
- ACT_SITE 119 119
- Gene Ontology Go:
- cell surface
cytosol
extracellular exosome
integral component of membrane
membrane
nucleus
plasma membrane
NAD(P)+ nucleosidase activity
NAD+ nucleosidase activity
phosphorus-oxygen lyase activity
transferase activity
apoptotic signaling pathway
B cell receptor signaling pathway
female pregnancy
long term synaptic depression
negative regulation of apoptotic process
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of B cell proliferation
positive regulation of cell growth
positive regulation of cytosolic calcium ion concentration
positive regulation of insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
response to drug
response to estradiol
response to hydroperoxide
response to hypoxia
response to interleukin-1
response to progesterone
response to retinoic acid
signal transduction - Gene Ontology Biological Process:
- apoptotic signaling pathway
B cell receptor signaling pathway
female pregnancy
long term synaptic depression
negative regulation of apoptotic process
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of B cell proliferation
positive regulation of cell growth
positive regulation of cytosolic calcium ion concentration
positive regulation of insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
response to drug
response to estradiol
response to hydroperoxide
response to hypoxia
response to interleukin-1
response to progesterone
response to retinoic acid
signal transduction - Gene Ontology Molecular Function:
- NAD(P)+ nucleosidase activity
NAD+ nucleosidase activity
phosphorus-oxygen lyase activity
transferase activity - Gene Ontology Cellular Component:
- cell surface
cytosol
extracellular exosome
integral component of membrane
membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Diabetes mellitus
Disulfide bond
Glycoprotein
Hydrolase
Membrane
NAD
NADP
Polymorphism
Receptor
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix