Names & Taxonomy

Uniprot ID:
P28827
Entry Name:
PTPRM_HUMAN
Status:
reviewed
Protein Names:
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
Gene Names:
PTPRM PTPRL1
Gene Names Primary:
PTPRM
Organism:
Homo sapiens (Human)

Structure

Length:
1452
Sequence:
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Active Site:
ACT_SITE 1095 1095 Phosphocysteine intermediate.
Gene Ontology Go:
cell-cell adherens junction
cell-cell junction
cytoplasm
integral component of plasma membrane
lamellipodium
perinuclear region of cytoplasm
cadherin binding
identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
neuron projection development
peptidyl-tyrosine dephosphorylation
positive regulation of vasodilation
protein dephosphorylation
response to drug
retina layer formation
retinal ganglion cell axon guidance
signal transduction
Gene Ontology Biological Process:
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
neuron projection development
peptidyl-tyrosine dephosphorylation
positive regulation of vasodilation
protein dephosphorylation
response to drug
retina layer formation
retinal ganglion cell axon guidance
signal transduction
Gene Ontology Molecular Function:
cadherin binding
identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
cell-cell adherens junction
cell-cell junction
cytoplasm
integral component of plasma membrane
lamellipodium
perinuclear region of cytoplasm
Keywords:
3D-structure
Alternative splicing
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Itself; P09803

Publication

PubMed ID:
1655529 16177791 15489334 16335952 18669648 9346878 16456543