Names & Taxonomy
- Uniprot ID:
- P28827
- Entry Name:
- PTPRM_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
- Gene Names:
- PTPRM PTPRL1
- Gene Names Primary:
- PTPRM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1452
- Sequence:
- MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Active Site:
- ACT_SITE 1095 1095 Phosphocysteine intermediate.
- Gene Ontology Go:
- cell-cell adherens junction
cell-cell junction
cytoplasm
integral component of plasma membrane
lamellipodium
perinuclear region of cytoplasm
cadherin binding
identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
neuron projection development
peptidyl-tyrosine dephosphorylation
positive regulation of vasodilation
protein dephosphorylation
response to drug
retina layer formation
retinal ganglion cell axon guidance
signal transduction - Gene Ontology Biological Process:
- homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of angiogenesis
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
neuron projection development
peptidyl-tyrosine dephosphorylation
positive regulation of vasodilation
protein dephosphorylation
response to drug
retina layer formation
retinal ganglion cell axon guidance
signal transduction - Gene Ontology Molecular Function:
- cadherin binding
identical protein binding
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- cell-cell adherens junction
cell-cell junction
cytoplasm
integral component of plasma membrane
lamellipodium
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Itself; P09803