Names & Taxonomy
- Uniprot ID:
- P28702
- Entry Name:
- RXRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
- Gene Names:
- RXRB NR2B2
- Gene Names Primary:
- RXRB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 533
- Sequence:
- MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQTPEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
- Cross Reference Drug Bank:
- DB00459 DB00210 DB00523 DB00307 DB00799 DB00755
- Gene Ontology Go:
- nucleoplasm
nucleus
9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
thyroid hormone receptor coactivator activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding
gene expression
positive regulation of transcription from RNA polymerase II promoter
regulation of myelination
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- gene expression
positive regulation of transcription from RNA polymerase II promoter
regulation of myelination
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- 9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid hormone receptor activity
thyroid hormone receptor coactivator activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- Q00975; P10276