Names & Taxonomy
- Uniprot ID:
- P28329
- Entry Name:
- CLAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6)
- Gene Names:
- CHAT
- Gene Names Primary:
- CHAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 748
- Sequence:
- MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMAAKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEKATRPSQGHQP
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
- Catalytic Activity:
- Acetyl-CoA + choline = CoA + O-acetylcholine.
- Active Site:
- ACT_SITE 442 442 Proton acceptor.
- Cross Reference Drug Bank:
- DB00122 DB00184
- Gene Ontology Go:
- cytoplasm
cytosol
neuron projection
nucleus
presynapse
choline binding
choline O-acetyltransferase activity
acetylcholine biosynthetic process
antral ovarian follicle growth
glycerophospholipid biosynthetic process
memory
neurotransmitter secretion
phosphatidylcholine biosynthetic process
phospholipid metabolic process
response to drug
response to ethanol
response to hypoxia
response to nutrient
small molecule metabolic process
synaptic transmission - Gene Ontology Biological Process:
- acetylcholine biosynthetic process
antral ovarian follicle growth
glycerophospholipid biosynthetic process
memory
neurotransmitter secretion
phosphatidylcholine biosynthetic process
phospholipid metabolic process
response to drug
response to ethanol
response to hypoxia
response to nutrient
small molecule metabolic process
synaptic transmission - Gene Ontology Molecular Function:
- choline binding
choline O-acetyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
neuron projection
nucleus
presynapse - Keywords:
- 3D-structure
Acyltransferase
Alternative splicing
Complete proteome
Congenital myasthenic syndrome
Direct protein sequencing
Disease mutation
Neurotransmitter biosynthesis
Phosphoprotein
Polymorphism
Reference proteome
Transferase