Names & Taxonomy
- Uniprot ID:
- P28222
- Entry Name:
- 5HT1B_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)
- Gene Names:
- HTR1B HTR1DB
- Gene Names Primary:
- HTR1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
- Cross Reference Drug Bank:
- DB00918 DB00321 DB00543 DB00714 DB01238 DB06216 DB08807 DB01200 DB00248 DB00363 DB00320 DB00216 DB01049 DB00696 DB00998 DB01221 DB00589 DB00408 DB00247 DB00952 DB00334 DB00904 DB01359 DB01186 DB00960 DB00413 DB00571 DB01224 DB00953 DB00268 DB00669 DB09068 DB01392 DB00246 DB00315
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
plasma membrane
drug binding
G-protein coupled serotonin receptor activity
serotonin binding
adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
cellular response to drug
cellular response to temperature stimulus
drinking behavior
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cAMP biosynthetic process
negative regulation of serotonin secretion
negative regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, glutamatergic
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of behavior
regulation of dopamine secretion
response to cocaine
response to ethanol
response to mineralocorticoid
synaptic transmission
vasoconstriction - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
cellular response to drug
cellular response to temperature stimulus
drinking behavior
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cAMP biosynthetic process
negative regulation of serotonin secretion
negative regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, glutamatergic
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of behavior
regulation of dopamine secretion
response to cocaine
response to ethanol
response to mineralocorticoid
synaptic transmission
vasoconstriction - Gene Ontology Molecular Function:
- drug binding
G-protein coupled serotonin receptor activity
serotonin binding - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Behavior
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q99750