Names & Taxonomy

Uniprot ID:
P28222
Entry Name:
5HT1B_HUMAN
Status:
reviewed
Protein Names:
5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)
Gene Names:
HTR1B HTR1DB
Gene Names Primary:
HTR1B
Organism:
Homo sapiens (Human)

Structure

Length:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Cross Reference Drug Bank:
DB00918 DB00321 DB00543 DB00714 DB01238 DB06216 DB08807 DB01200 DB00248 DB00363 DB00320 DB00216 DB01049 DB00696 DB00998 DB01221 DB00589 DB00408 DB00247 DB00952 DB00334 DB00904 DB01359 DB01186 DB00960 DB00413 DB00571 DB01224 DB00953 DB00268 DB00669 DB09068 DB01392 DB00246 DB00315
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
plasma membrane
drug binding
G-protein coupled serotonin receptor activity
serotonin binding
adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
cellular response to drug
cellular response to temperature stimulus
drinking behavior
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cAMP biosynthetic process
negative regulation of serotonin secretion
negative regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, glutamatergic
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of behavior
regulation of dopamine secretion
response to cocaine
response to ethanol
response to mineralocorticoid
synaptic transmission
vasoconstriction
Gene Ontology Biological Process:
adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
cellular response to drug
cellular response to temperature stimulus
drinking behavior
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cAMP biosynthetic process
negative regulation of serotonin secretion
negative regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, glutamatergic
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of behavior
regulation of dopamine secretion
response to cocaine
response to ethanol
response to mineralocorticoid
synaptic transmission
vasoconstriction
Gene Ontology Molecular Function:
drug binding
G-protein coupled serotonin receptor activity
serotonin binding
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
plasma membrane
Keywords:
3D-structure
Behavior
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Interacts With:
Q99750

Publication

PubMed ID:
1315531 1610347 1348246 1559993 1565658 1351684 1328844 15014171 14574404 15489334 8218242 10452531 15853772 18476671 20945968 23519215 23519210 7802650