Names & Taxonomy

Uniprot ID:
P27824
Entry Name:
CALX_HUMAN
Status:
reviewed
Protein Names:
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene Names:
CANX
Gene Names Primary:
CANX
Organism:
Homo sapiens (Human)

Structure

Length:
592
Sequence:
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Cross Reference Drug Bank:
DB00025 DB00031
Gene Ontology Go:
axon
dendrite cytoplasm
dendritic spine
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of lumenal side of endoplasmic reticulum membrane
melanosome
membrane
myelin sheath
neuronal cell body
protein complex
ribosome
rough endoplasmic reticulum
smooth endoplasmic reticulum
calcium ion binding
carbohydrate binding
poly(A) RNA binding
aging
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
chaperone-mediated protein folding
clathrin-mediated endocytosis
post-translational protein modification
protein folding
protein folding in endoplasmic reticulum
protein N-linked glycosylation via asparagine
protein secretion
synaptic vesicle endocytosis
Gene Ontology Biological Process:
aging
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
chaperone-mediated protein folding
clathrin-mediated endocytosis
post-translational protein modification
protein folding
protein folding in endoplasmic reticulum
protein N-linked glycosylation via asparagine
protein secretion
synaptic vesicle endocytosis
Gene Ontology Molecular Function:
calcium ion binding
carbohydrate binding
poly(A) RNA binding
Gene Ontology Cellular Component:
axon
dendrite cytoplasm
dendritic spine
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of lumenal side of endoplasmic reticulum membrane
melanosome
membrane
myelin sheath
neuronal cell body
protein complex
ribosome
rough endoplasmic reticulum
smooth endoplasmic reticulum
Keywords:
Acetylation
Alternative splicing
Calcium
Chaperone
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Lectin
Lipoprotein
Membrane
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
P11607; P13569; Q92597; P41143; P30050; P61619; P43307

Publication

PubMed ID:
8486646 8136357 8055875 14702039 15372022 15489334 1326756 1286667 12643545 17081983 16361248 17081065 18088087 18691976 18669648 18318008 19369195 19690332 19608861 20801878 20068231 21269460 21205830 22016385 21406692 22314232 23826168 24275569 25944712