Names & Taxonomy
- Uniprot ID:
- P27824
- Entry Name:
- CALX_HUMAN
- Status:
- reviewed
- Protein Names:
- Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
- Gene Names:
- CANX
- Gene Names Primary:
- CANX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 592
- Sequence:
- MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
- Cross Reference Drug Bank:
- DB00025 DB00031
- Gene Ontology Go:
- axon
dendrite cytoplasm
dendritic spine
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of lumenal side of endoplasmic reticulum membrane
melanosome
membrane
myelin sheath
neuronal cell body
protein complex
ribosome
rough endoplasmic reticulum
smooth endoplasmic reticulum
calcium ion binding
carbohydrate binding
poly(A) RNA binding
aging
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
chaperone-mediated protein folding
clathrin-mediated endocytosis
post-translational protein modification
protein folding
protein folding in endoplasmic reticulum
protein N-linked glycosylation via asparagine
protein secretion
synaptic vesicle endocytosis - Gene Ontology Biological Process:
- aging
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
chaperone-mediated protein folding
clathrin-mediated endocytosis
post-translational protein modification
protein folding
protein folding in endoplasmic reticulum
protein N-linked glycosylation via asparagine
protein secretion
synaptic vesicle endocytosis - Gene Ontology Molecular Function:
- calcium ion binding
carbohydrate binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- axon
dendrite cytoplasm
dendritic spine
endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum membrane
ER-mitochondrion membrane contact site
extracellular exosome
integral component of lumenal side of endoplasmic reticulum membrane
melanosome
membrane
myelin sheath
neuronal cell body
protein complex
ribosome
rough endoplasmic reticulum
smooth endoplasmic reticulum - Keywords:
- Acetylation
Alternative splicing
Calcium
Chaperone
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Lectin
Lipoprotein
Membrane
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- P11607; P13569; Q92597; P41143; P30050; P61619; P43307