Names & Taxonomy
- Uniprot ID:
- P27544
- Entry Name:
- CERS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ceramide synthase 1 (CerS1) (LAG1 longevity assurance homolog 1) (Longevity assurance gene 1 protein homolog 1) (Protein UOG-1)
- Gene Names:
- CERS1 LAG1 LASS1 UOG1
- Gene Names Primary:
- CERS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 350
- Sequence:
- MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPELLLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity).
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
sphingosine N-acyltransferase activity
cellular response to dithiothreitol
cellular response to drug
cellular response to mycotoxin
cellular response to UV-A
ceramide biosynthetic process
negative regulation of telomerase activity
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- cellular response to dithiothreitol
cellular response to drug
cellular response to mycotoxin
cellular response to UV-A
ceramide biosynthetic process
negative regulation of telomerase activity
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- sphingosine N-acyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Disease mutation
Endoplasmic reticulum
Epilepsy
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Transmembrane
Transmembrane helix