Names & Taxonomy
- Uniprot ID:
- P27487
- Entry Name:
- DPP4_HUMAN
- Status:
- reviewed
- Protein Names:
- Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
- Gene Names:
- DPP4 ADCP2 CD26
- Gene Names Primary:
- DPP4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 766
- Sequence:
- MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Dipeptidyl peptidase 4 soluble form: Secreted
Function
- Function:
- Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
- Catalytic Activity:
- Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by GPC3 and diprotin A.
- Active Site:
- ACT_SITE 630 630 Charge relay system.
- Cross Reference Drug Bank:
- DB06203 DB01076 DB08882 DB06655 DB06335 DB01261 DB04876
- Gene Ontology Go:
- apical plasma membrane
cell surface
endocytic vesicle
extracellular exosome
focal adhesion
integral component of membrane
intercellular canaliculus
invadopodium membrane
lamellipodium
lamellipodium membrane
lysosomal membrane
membrane
membrane raft
plasma membrane
dipeptidyl-peptidase activity
identical protein binding
protease binding
protein homodimerization activity
receptor binding
serine-type endopeptidase activity
serine-type peptidase activity
virus receptor activity
behavioral fear response
endothelial cell migration
locomotory exploration behavior
negative regulation of extracellular matrix disassembly
positive regulation of cell proliferation
psychomotor behavior
regulation of cell-cell adhesion mediated by integrin
response to hypoxia
T cell activation
T cell costimulation
viral entry into host cell - Gene Ontology Biological Process:
- behavioral fear response
endothelial cell migration
locomotory exploration behavior
negative regulation of extracellular matrix disassembly
positive regulation of cell proliferation
psychomotor behavior
regulation of cell-cell adhesion mediated by integrin
response to hypoxia
T cell activation
T cell costimulation
viral entry into host cell - Gene Ontology Molecular Function:
- dipeptidyl-peptidase activity
identical protein binding
protease binding
protein homodimerization activity
receptor binding
serine-type endopeptidase activity
serine-type peptidase activity
virus receptor activity - Gene Ontology Cellular Component:
- apical plasma membrane
cell surface
endocytic vesicle
extracellular exosome
focal adhesion
integral component of membrane
intercellular canaliculus
invadopodium membrane
lamellipodium
lamellipodium membrane
lysosomal membrane
membrane
membrane raft
plasma membrane - Keywords:
- 3D-structure
Aminopeptidase
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Protease
Receptor
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane
Transmembrane helix - Interacts With:
- Itself; P56658; P51671; P02778; O14625; P19875; Q07325; P01275; P01282
Publication
- PubMed ID:
- 1352704 1347043 1352530 7927537 19054851 15815621 15489334 1977364 7487939 1677636 10951221 17549790 8096237 8101391 7907293 8526932 9413751 10570924 10593948 11027426 10880264 10900005 11772392 11773049 12676959 15448155 14691230 16335952 16651416 17287217 18708048 19557413 19159218 21269460 23486063 24275569 12832764 12646248 12483204 12906826 20684603