Names & Taxonomy
- Uniprot ID:
- P27338
- Entry Name:
- AOFB_HUMAN
- Status:
- reviewed
- Protein Names:
- Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)
- Gene Names:
- MAOB
- Gene Names Primary:
- MAOB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 520
- Sequence:
- MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Function
- Function:
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
- Catalytic Activity:
- RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB00915 DB00182 DB00988 DB01363 DB03147 DB00614 DB01247 DB00601 DB01577 DB01171 DB08804 DB00184 DB01626 DB00780 DB00191 DB00721 DB01367 DB01037 DB01104 DB00752 DB00909
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion
electron carrier activity
flavin adenine dinucleotide binding
primary amine oxidase activity
dopamine catabolic process
hydrogen peroxide biosynthetic process
negative regulation of serotonin secretion
positive regulation of dopamine metabolic process
response to aluminum ion
response to corticosterone
response to drug
response to ethanol
response to lipopolysaccharide
response to selenium ion
response to toxic substance
small molecule metabolic process
substantia nigra development
xenobiotic metabolic process - Gene Ontology Biological Process:
- dopamine catabolic process
hydrogen peroxide biosynthetic process
negative regulation of serotonin secretion
positive regulation of dopamine metabolic process
response to aluminum ion
response to corticosterone
response to drug
response to ethanol
response to lipopolysaccharide
response to selenium ion
response to toxic substance
small molecule metabolic process
substantia nigra development
xenobiotic metabolic process - Gene Ontology Molecular Function:
- electron carrier activity
flavin adenine dinucleotide binding
primary amine oxidase activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
mitochondrial envelope
mitochondrial inner membrane
mitochondrial outer membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
FAD
Flavoprotein
Membrane
Mitochondrion
Mitochondrion outer membrane
Oxidoreductase
Reference proteome
Transmembrane
Transmembrane helix