Names & Taxonomy

Uniprot ID:
P26640
Entry Name:
SYVC_HUMAN
Status:
reviewed
Protein Names:
Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)
Gene Names:
VARS G7A VARS2
Gene Names Primary:
VARS
Organism:
Homo sapiens (Human)

Structure

Length:
1264
Sequence:
MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPALEQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGLRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPARRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKKREKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSYSPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQNDYEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWCISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMPQAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARELGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALFQKML
Proteomes:
UP000005640

Function

Catalytic Activity:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).
Enzyme Regulation:
ENZYME REGULATION: Can be regulated by protein kinase C-dependent phosphorylation.
Cross Reference Drug Bank:
DB00161
Gene Ontology Go:
cytosol
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
valine-tRNA ligase activity
gene expression
tRNA aminoacylation for protein translation
valyl-tRNA aminoacylation
Gene Ontology Biological Process:
gene expression
tRNA aminoacylation for protein translation
valyl-tRNA aminoacylation
Gene Ontology Molecular Function:
aminoacyl-tRNA editing activity
ATP binding
valine-tRNA ligase activity
Gene Ontology Cellular Component:
cytosol
mitochondrion
Keywords:
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Direct protein sequencing
Ligase
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Interacts With:
Q13137

Publication

PubMed ID:
1898367 14656967 14702039 14574404 15489334 8428657 19608861 21269460 22223895 22814378 24275569 25944712