Names & Taxonomy
- Uniprot ID:
- P26640
- Entry Name:
- SYVC_HUMAN
- Status:
- reviewed
- Protein Names:
- Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)
- Gene Names:
- VARS G7A VARS2
- Gene Names Primary:
- VARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1264
- Sequence:
- MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPALEQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGLRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPARRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKKREKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSYSPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQNDYEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWCISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMPQAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARELGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALFQKML
- Proteomes:
- UP000005640
Function
- Catalytic Activity:
- ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).
- Enzyme Regulation:
- ENZYME REGULATION: Can be regulated by protein kinase C-dependent phosphorylation.
- Cross Reference Drug Bank:
- DB00161
- Gene Ontology Go:
- cytosol
mitochondrion
aminoacyl-tRNA editing activity
ATP binding
valine-tRNA ligase activity
gene expression
tRNA aminoacylation for protein translation
valyl-tRNA aminoacylation - Gene Ontology Biological Process:
- gene expression
tRNA aminoacylation for protein translation
valyl-tRNA aminoacylation - Gene Ontology Molecular Function:
- aminoacyl-tRNA editing activity
ATP binding
valine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytosol
mitochondrion - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Direct protein sequencing
Ligase
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome - Interacts With:
- Q13137