Names & Taxonomy
- Uniprot ID:
- P26010
- Entry Name:
- ITB7_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin beta-7 (Gut homing receptor beta subunit)
- Gene Names:
- ITGB7
- Gene Names Primary:
- ITGB7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 798
- Sequence:
- MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
- Cross Reference Drug Bank:
- DB09033
- Gene Ontology Go:
- cell surface
extracellular exosome
integrin alpha4-beta7 complex
integrin complex
membrane
plasma membrane
receptor complex
cell adhesion molecule binding
metal ion binding
virus receptor activity
cell adhesion
cell-matrix adhesion
cell-matrix adhesion involved in ameboidal cell migration
extracellular matrix organization
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte tethering or rolling
receptor clustering
regulation of immune response
substrate adhesion-dependent cell spreading
T cell migration - Gene Ontology Biological Process:
- cell adhesion
cell-matrix adhesion
cell-matrix adhesion involved in ameboidal cell migration
extracellular matrix organization
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte tethering or rolling
receptor clustering
regulation of immune response
substrate adhesion-dependent cell spreading
T cell migration - Gene Ontology Molecular Function:
- cell adhesion molecule binding
metal ion binding
virus receptor activity - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
integrin alpha4-beta7 complex
integrin complex
membrane
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Integrin
Magnesium
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P21333; P13612