Names & Taxonomy
- Uniprot ID:
- P25705
- Entry Name:
- ATPA_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP synthase subunit alpha, mitochondrial
- Gene Names:
- ATP5A1 ATP5A ATP5AL2 ATPM
- Gene Names Primary:
- ATP5A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 553
- Sequence:
- MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
- Gene Ontology Go:
- extracellular exosome
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrion
myelin sheath
plasma membrane
proton-transporting ATP synthase complex, catalytic core F(1)
ATP binding
MHC class I protein binding
poly(A) RNA binding
proton-transporting ATP synthase activity, rotational mechanism
proton-transporting ATPase activity, rotational mechanism
transmembrane transporter activity
ATP biosynthetic process
ATP hydrolysis coupled proton transport
cellular metabolic process
embryo development
lipid metabolic process
mitochondrial ATP synthesis coupled proton transport
negative regulation of endothelial cell proliferation
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Biological Process:
- ATP biosynthetic process
ATP hydrolysis coupled proton transport
cellular metabolic process
embryo development
lipid metabolic process
mitochondrial ATP synthesis coupled proton transport
negative regulation of endothelial cell proliferation
respiratory electron transport chain
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
MHC class I protein binding
poly(A) RNA binding
proton-transporting ATPase activity, rotational mechanism
proton-transporting ATP synthase activity, rotational mechanism
transmembrane transporter activity - Gene Ontology Cellular Component:
- extracellular exosome
membrane
mitochondrial inner membrane
mitochondrial matrix
mitochondrial proton-transporting ATP synthase complex
mitochondrion
myelin sheath
plasma membrane
proton-transporting ATP synthase complex, catalytic core F(1) - Keywords:
- ATP synthesis
ATP-binding
Acetylation
Alternative splicing
CF(1)
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Hydrogen ion transport
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Transit peptide
Transport - Interacts With:
- P78537; Q9NTG7; P63104