Names & Taxonomy
- Uniprot ID:
- P25116
- Entry Name:
- PAR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
- Gene Names:
- F2R CF2R PAR1 TR
- Gene Names Primary:
- F2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 425
- Sequence:
- MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
- Cross Reference Drug Bank:
- DB00086 DB09030
- Gene Ontology Go:
- caveola
cell surface
cytosol
early endosome
extracellular region
Golgi apparatus
integral component of plasma membrane
late endosome
neuromuscular junction
plasma membrane
platelet dense tubular network
postsynaptic membrane
G-protein alpha-subunit binding
G-protein beta-subunit binding
G-protein coupled receptor activity
receptor binding
thrombin receptor activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of MAPKK activity
anatomical structure morphogenesis
blood coagulation
connective tissue replacement involved in inflammatory response wound healing
establishment of synaptic specificity at neuromuscular junction
G-protein coupled receptor signaling pathway
homeostasis of number of cells within a tissue
inflammatory response
negative regulation of cell proliferation
negative regulation of glomerular filtration
negative regulation of neuron apoptotic process
negative regulation of renin secretion into blood stream
phospholipase C-activating G-protein coupled receptor signaling pathway
platelet activation
platelet dense granule organization
positive regulation of blood coagulation
positive regulation of calcium ion transport
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of collagen biosynthetic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-6 secretion
positive regulation of interleukin-8 secretion
positive regulation of JAK-STAT cascade
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of Rho protein signal transduction
positive regulation of smooth muscle contraction
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of blood coagulation
regulation of interleukin-1 beta production
regulation of sensory perception of pain
release of sequestered calcium ion into cytosol
response to lipopolysaccharide
response to wounding
STAT protein import into nucleus
tyrosine phosphorylation of STAT protein - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of MAPKK activity
anatomical structure morphogenesis
blood coagulation
connective tissue replacement involved in inflammatory response wound healing
establishment of synaptic specificity at neuromuscular junction
G-protein coupled receptor signaling pathway
homeostasis of number of cells within a tissue
inflammatory response
negative regulation of cell proliferation
negative regulation of glomerular filtration
negative regulation of neuron apoptotic process
negative regulation of renin secretion into blood stream
phospholipase C-activating G-protein coupled receptor signaling pathway
platelet activation
platelet dense granule organization
positive regulation of blood coagulation
positive regulation of calcium ion transport
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of collagen biosynthetic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-6 secretion
positive regulation of interleukin-8 secretion
positive regulation of JAK-STAT cascade
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of Rho protein signal transduction
positive regulation of smooth muscle contraction
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of blood coagulation
regulation of interleukin-1 beta production
regulation of sensory perception of pain
release of sequestered calcium ion into cytosol
response to lipopolysaccharide
response to wounding
STAT protein import into nucleus
tyrosine phosphorylation of STAT protein - Gene Ontology Molecular Function:
- G-protein alpha-subunit binding
G-protein beta-subunit binding
G-protein coupled receptor activity
receptor binding
thrombin receptor activity - Gene Ontology Cellular Component:
- caveola
cell surface
cytosol
early endosome
extracellular region
Golgi apparatus
integral component of plasma membrane
late endosome
neuromuscular junction
plasma membrane
platelet dense tubular network
postsynaptic membrane - Keywords:
- 3D-structure
Blood coagulation
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hemostasis
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q03135; Q9UNN8