Names & Taxonomy
- Uniprot ID:
- P25100
- Entry Name:
- ADA1D_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a)
- Gene Names:
- ADRA1D ADRA1A
- Gene Names Primary:
- ADRA1D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 572
- Sequence:
- MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
- Cross Reference Drug Bank:
- DB00346 DB00321 DB00543 DB00182 DB01200 DB00248 DB01136 DB00477 DB00575 DB00298 DB01151 DB00590 DB01142 DB04855 DB06262 DB00668 DB01049 DB00696 DB00800 DB00458 DB00598 DB00934 DB01365 DB01403 DB00723 DB06148 DB00211 DB00370 DB00622 DB00368 DB00540 DB00935 DB01186 DB00925 DB00388 DB00457 DB00420 DB00777 DB01224 DB06144 DB06207 DB00706 DB01162 DB06694
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
alpha1-adrenergic receptor activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell proliferation
cell-cell signaling
DNA metabolic process
G-protein coupled receptor signaling pathway
multicellular organism development
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction - Gene Ontology Biological Process:
- adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cell-cell signaling
cell proliferation
DNA metabolic process
G-protein coupled receptor signaling pathway
multicellular organism development
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction - Gene Ontology Molecular Function:
- alpha1-adrenergic receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix