Names & Taxonomy

Uniprot ID:
P25067
Entry Name:
CO8A2_HUMAN
Status:
reviewed
Protein Names:
Collagen alpha-2(VIII) chain (Endothelial collagen)
Gene Names:
COL8A2
Gene Names Primary:
COL8A2
Organism:
Homo sapiens (Human)

Structure

Length:
703
Sequence:
MLGTLTPLSSLLLLLLVLVLGCGPRASSGGGAGGAAGYAPVKYIQPMQKGPVGPPFREGKGQYLEMPLPLLPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVPGPPGFQGEPGPQGEPGPPGDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGVPGPRGEPGAVGPKGPPGVDGVGVPGAAGLPGPQGPSGAKGEPGTRGPPGLIGPTGYGMPGLPGPKGDRGPAGVPGLLGDRGEPGEDGEPGEQGPQGLGGPPGLPGSAGLPGRRGPPGPKGEAGPGGPPGVPGIRGDQGPSGLAGKPGVPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPGQPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPGITGPPGPPGPPGPPGAPGAFDETGIAGLHLPNGGVEGAVLGKGGKPQFGLGELSAHATPAFTAVLTSPFPASGMPVKFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHVKGTNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQVWVQMPSDQANGLYSTEYIHSSFSGFLLCPT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.

Function

Function:
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).
Gene Ontology Go:
basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular region
proteinaceous extracellular matrix
extracellular matrix structural constituent
protein binding, bridging
angiogenesis
camera-type eye morphogenesis
collagen catabolic process
epithelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
single organismal cell-cell adhesion
Gene Ontology Biological Process:
angiogenesis
camera-type eye morphogenesis
collagen catabolic process
epithelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
single organismal cell-cell adhesion
Gene Ontology Molecular Function:
extracellular matrix structural constituent
protein binding, bridging
Gene Ontology Cellular Component:
basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular region
proteinaceous extracellular matrix
Keywords:
Angiogenesis
Basement membrane
Cell adhesion
Collagen
Complete proteome
Corneal dystrophy
Disease mutation
Extracellular matrix
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
14702039 16710414 2019595 1515454 10686422 14990571 17888087 11689488 15175909