Names & Taxonomy
- Uniprot ID:
- P25067
- Entry Name:
- CO8A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-2(VIII) chain (Endothelial collagen)
- Gene Names:
- COL8A2
- Gene Names Primary:
- COL8A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 703
- Sequence:
- MLGTLTPLSSLLLLLLVLVLGCGPRASSGGGAGGAAGYAPVKYIQPMQKGPVGPPFREGKGQYLEMPLPLLPMDLKGEPGPPGKPGPRGPPGPPGFPGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGPPGPPGLPGPSGITIPGKPGAQGVPGPPGFQGEPGPQGEPGPPGDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGVPGPRGEPGAVGPKGPPGVDGVGVPGAAGLPGPQGPSGAKGEPGTRGPPGLIGPTGYGMPGLPGPKGDRGPAGVPGLLGDRGEPGEDGEPGEQGPQGLGGPPGLPGSAGLPGRRGPPGPKGEAGPGGPPGVPGIRGDQGPSGLAGKPGVPGERGLPGAHGPPGPTGPKGEPGFTGRPGGPGVAGALGQKGDLGLPGQPGLRGPSGIPGLQGPAGPIGPQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPGITGPPGPPGPPGPPGAPGAFDETGIAGLHLPNGGVEGAVLGKGGKPQFGLGELSAHATPAFTAVLTSPFPASGMPVKFDRTLYNGHSGYNPATGIFTCPVGGVYYFAYHVHVKGTNVWVALYKNNVPATYTYDEYKKGYLDQASGGAVLQLRPNDQVWVQMPSDQANGLYSTEYIHSSFSGFLLCPT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix, basement membrane.
Function
- Function:
- Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity).
- Gene Ontology Go:
- basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular region
proteinaceous extracellular matrix
extracellular matrix structural constituent
protein binding, bridging
angiogenesis
camera-type eye morphogenesis
collagen catabolic process
epithelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
single organismal cell-cell adhesion - Gene Ontology Biological Process:
- angiogenesis
camera-type eye morphogenesis
collagen catabolic process
epithelial cell proliferation
extracellular matrix disassembly
extracellular matrix organization
single organismal cell-cell adhesion - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
protein binding, bridging - Gene Ontology Cellular Component:
- basement membrane
collagen trimer
endoplasmic reticulum lumen
extracellular region
proteinaceous extracellular matrix - Keywords:
- Angiogenesis
Basement membrane
Cell adhesion
Collagen
Complete proteome
Corneal dystrophy
Disease mutation
Extracellular matrix
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal