Names & Taxonomy
- Uniprot ID:
- P25021
- Entry Name:
- HRH2_HUMAN
- Status:
- reviewed
- Protein Names:
- Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
- Gene Names:
- HRH2
- Gene Names Primary:
- HRH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 359
- Sequence:
- MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
- Cross Reference Drug Bank:
- DB00321 DB06216 DB00272 DB00501 DB01142 DB00751 DB00927 DB00667 DB00408 DB00940 DB00585 DB00334 DB00863 DB08806 DB00797
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
histamine receptor activity
digestive tract development
epithelial cell morphogenesis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
gastrin-induced gastric acid secretion
gland development
histamine-induced gastric acid secretion
immune response
memory
positive regulation of vasoconstriction
regulation of synaptic plasticity
toxin transport
visual learning - Gene Ontology Biological Process:
- digestive tract development
epithelial cell morphogenesis
gastrin-induced gastric acid secretion
gland development
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
histamine-induced gastric acid secretion
immune response
memory
positive regulation of vasoconstriction
regulation of synaptic plasticity
toxin transport
visual learning - Gene Ontology Molecular Function:
- histamine receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix