Names & Taxonomy
- Uniprot ID:
- P24752
- Entry Name:
- THIL_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)
- Gene Names:
- ACAT1 ACAT MAT
- Gene Names Primary:
- ACAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 427
- Sequence:
- MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Plays a major role in ketone body metabolism.
- Catalytic Activity:
- 2 acetyl-CoA = CoA + acetoacetyl-CoA.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4 uM for acetoacetyl coenzyme A
- Enzyme Regulation:
- ENZYME REGULATION: Activated by potassium ions, but not sodium ions.
- Active Site:
- ACT_SITE 126 126 Acyl-thioester intermediate.
- Cross Reference Drug Bank:
- DB00795
- Gene Ontology Go:
- extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
acetyl-CoA C-acetyltransferase activity
coenzyme binding
metal ion binding
adipose tissue development
brain development
branched-chain amino acid catabolic process
cellular ketone body metabolic process
cellular lipid metabolic process
cellular nitrogen compound metabolic process
ketone body biosynthetic process
ketone body catabolic process
liver development
metanephric proximal convoluted tubule development
protein homooligomerization
response to hormone
response to organic cyclic compound
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- adipose tissue development
brain development
branched-chain amino acid catabolic process
cellular ketone body metabolic process
cellular lipid metabolic process
cellular nitrogen compound metabolic process
ketone body biosynthetic process
ketone body catabolic process
liver development
metanephric proximal convoluted tubule development
protein homooligomerization
response to hormone
response to organic cyclic compound
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- acetyl-CoA C-acetyltransferase activity
coenzyme binding
metal ion binding - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Metal-binding
Mitochondrion
Polymorphism
Potassium
Reference proteome
Transferase
Transit peptide