Names & Taxonomy

Uniprot ID:
P24530
Entry Name:
EDNRB_HUMAN
Status:
reviewed
Protein Names:
Endothelin B receptor (ET-B) (ET-BR) (Endothelin receptor non-selective type)
Gene Names:
EDNRB ETRB
Gene Names Primary:
EDNRB
Organism:
Homo sapiens (Human)

Structure

Length:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cross Reference Drug Bank:
DB06403 DB00559 DB08932 DB06268
Gene Ontology Go:
cytosol
integral component of plasma membrane
membrane raft
nuclear membrane
plasma membrane
endothelin receptor activity
peptide hormone binding
aging
cell surface receptor signaling pathway
cellular response to lipopolysaccharide
cGMP-mediated signaling
endothelin receptor signaling pathway
enteric nervous system development
enteric smooth muscle cell differentiation
epithelial fluid transport
macrophage chemotaxis
melanocyte differentiation
negative regulation of adenylate cyclase activity
negative regulation of apoptotic process
negative regulation of cellular protein metabolic process
negative regulation of neuron maturation
negative regulation of transcription from RNA polymerase II promoter
nervous system development
neural crest cell migration
peripheral nervous system development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of penile erection
positive regulation of protein phosphorylation
positive regulation of renal sodium excretion
positive regulation of urine volume
posterior midgut development
regulation of blood pressure
regulation of epithelial cell proliferation
regulation of fever generation
regulation of pH
regulation of sensory perception of pain
response to organic cyclic compound
response to pain
sensory perception of pain
vasoconstriction
vasodilation
vein smooth muscle contraction
Gene Ontology Biological Process:
aging
cell surface receptor signaling pathway
cellular response to lipopolysaccharide
cGMP-mediated signaling
endothelin receptor signaling pathway
enteric nervous system development
enteric smooth muscle cell differentiation
epithelial fluid transport
macrophage chemotaxis
melanocyte differentiation
negative regulation of adenylate cyclase activity
negative regulation of apoptotic process
negative regulation of cellular protein metabolic process
negative regulation of neuron maturation
negative regulation of transcription from RNA polymerase II promoter
nervous system development
neural crest cell migration
peripheral nervous system development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of penile erection
positive regulation of protein phosphorylation
positive regulation of renal sodium excretion
positive regulation of urine volume
posterior midgut development
regulation of blood pressure
regulation of epithelial cell proliferation
regulation of fever generation
regulation of pH
regulation of sensory perception of pain
response to organic cyclic compound
response to pain
sensory perception of pain
vasoconstriction
vasodilation
vein smooth muscle contraction
Gene Ontology Molecular Function:
endothelin receptor activity
peptide hormone binding
Gene Ontology Cellular Component:
cytosol
integral component of plasma membrane
membrane raft
nuclear membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Deafness
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hirschsprung disease
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Waardenburg syndrome
Interacts With:
P05305

Publication

PubMed ID:
1710450 1648908 1713452 1282938 1291713 8429023 8440682 7536888 8810293 10072757 14702039 15057823 15489334 12628594 9284755 9261180 9359036 8001158 8634719 8852659 8852660 8630503 9760196 11471546 11891690 12189494