Names & Taxonomy

Uniprot ID:
P24298
Entry Name:
ALAT1_HUMAN
Status:
reviewed
Protein Names:
Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)
Gene Names:
GPT AAT1 GPT1
Gene Names Primary:
GPT
Organism:
Homo sapiens (Human)

Structure

Length:
496
Sequence:
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQLPPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAKFTLEYS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
Pathway:
Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
Catalytic Activity:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Cross Reference Drug Bank:
DB00160 DB00780
Gene Ontology Go:
cytosol
extracellular exosome
extracellular space
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
small molecule metabolic process
Gene Ontology Biological Process:
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
extracellular space
Keywords:
Acetylation
Aminotransferase
Complete proteome
Cytoplasm
Direct protein sequencing
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase

Publication

PubMed ID:
9119391 15489334 1931970 11863375 24275569 26477546