Names & Taxonomy
- Uniprot ID:
- P24298
- Entry Name:
- ALAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1)
- Gene Names:
- GPT AAT1 GPT1
- Gene Names Primary:
- GPT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQLPPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAKFTLEYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
- Pathway:
- Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
- Catalytic Activity:
- L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00160 DB00780
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space - Keywords:
- Acetylation
Aminotransferase
Complete proteome
Cytoplasm
Direct protein sequencing
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase