Names & Taxonomy
- Uniprot ID:
- P23921
- Entry Name:
- RIR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
- Gene Names:
- RRM1 RR1
- Gene Names Primary:
- RRM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 792
- Sequence:
- MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
- Pathway:
- Genetic information processing; DNA replication.
- Catalytic Activity:
- 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
- Enzyme Regulation:
- ENZYME REGULATION: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the M1 subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site, the dATP inhibition is mediated by AHCYL1 which stabilizes dATP in the site.
- Active Site:
- ACT_SITE 427 427 Proton acceptor.
- Cross Reference Drug Bank:
- DB00242 DB00631 DB01073 DB00441 DB01005
- Gene Ontology Go:
- cell projection
cytoplasm
cytosol
extracellular exosome
neuronal cell body
nuclear envelope
nucleoplasm
ribonucleoside-diphosphate reductase complex
ATP binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
cell proliferation in forebrain
deoxyribonucleotide biosynthetic process
DNA replication
male gonad development
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
pyrimidine nucleobase metabolic process
response to ionizing radiation
retina development in camera-type eye
small molecule metabolic process - Gene Ontology Biological Process:
- cell proliferation in forebrain
deoxyribonucleotide biosynthetic process
DNA replication
male gonad development
mitotic cell cycle
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
protein heterotetramerization
pyrimidine nucleobase metabolic process
response to ionizing radiation
retina development in camera-type eye
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - Gene Ontology Cellular Component:
- cell projection
cytoplasm
cytosol
extracellular exosome
neuronal cell body
nuclear envelope
nucleoplasm
ribonucleoside-diphosphate reductase complex - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Complete proteome
Cytoplasm
DNA replication
Disulfide bond
Nucleotide-binding
Oxidoreductase
Polymorphism
Reference proteome - Interacts With:
- P31350