Names & Taxonomy
- Uniprot ID:
- P23786
- Entry Name:
- CPT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)
- Gene Names:
- CPT2 CPT1
- Gene Names Primary:
- CPT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 658
- Sequence:
- MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMYLSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWAELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLGGFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
- Intramembrane:
- INTRAMEM 179 208 Note=Mitochondrial inner membrane.
Function
- Pathway:
- Lipid metabolism; fatty acid beta-oxidation.
- Catalytic Activity:
- Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
- Active Site:
- ACT_SITE 372 372 Proton acceptor.
- Cross Reference Drug Bank:
- DB00583 DB01074
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrion
nucleolus
nucleoplasm
carnitine O-palmitoyltransferase activity
carnitine shuttle
cellular lipid metabolic process
fatty acid beta-oxidation
small molecule metabolic process - Gene Ontology Biological Process:
- carnitine shuttle
cellular lipid metabolic process
fatty acid beta-oxidation
small molecule metabolic process - Gene Ontology Molecular Function:
- carnitine O-palmitoyltransferase activity
- Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrion
nucleolus
nucleoplasm - Keywords:
- Acetylation
Acyltransferase
Complete proteome
Direct protein sequencing
Disease mutation
Fatty acid metabolism
Lipid metabolism
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Transferase
Transit peptide
Transport