Names & Taxonomy
- Uniprot ID:
- P23677
- Entry Name:
- IP3KA_HUMAN
- Status:
- reviewed
- Protein Names:
- Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)
- Gene Names:
- ITPKA
- Gene Names Primary:
- ITPKA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 461
- Sequence:
- MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
- Proteomes:
- UP000005640
Function
- Catalytic Activity:
- ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: IP3K is activated by calmodulin.
- Gene Ontology Go:
- cytosol
dendritic spine
ATP binding
calmodulin-dependent protein kinase activity
inositol-1,4,5-trisphosphate 3-kinase activity
actin cytoskeleton organization
dendritic spine maintenance
inositol metabolic process
inositol phosphate metabolic process
positive regulation of dendritic spine morphogenesis
regulation of synaptic plasticity
signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- actin cytoskeleton organization
dendritic spine maintenance
inositol metabolic process
inositol phosphate metabolic process
positive regulation of dendritic spine morphogenesis
regulation of synaptic plasticity
signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
calmodulin-dependent protein kinase activity
inositol-1,4,5-trisphosphate 3-kinase activity - Gene Ontology Cellular Component:
- cytosol
dendritic spine - Keywords:
- 3D-structure
ATP-binding
Calmodulin-binding
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase