Names & Taxonomy
- Uniprot ID:
- P23526
- Entry Name:
- SAHH_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase)
- Gene Names:
- AHCY SAHH
- Gene Names Primary:
- AHCY
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 432
- Sequence:
- MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
- Pathway:
- Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
- Catalytic Activity:
- S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
- Cofactor:
- COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
melanosome
neuron projection
nucleus
adenosylhomocysteinase activity
adenyl nucleotide binding
NAD binding
cellular nitrogen compound metabolic process
chronic inflammatory response to antigenic stimulus
circadian sleep/wake cycle
homocysteine biosynthetic process
methylation
one-carbon metabolic process
response to hypoxia
response to nutrient
S-adenosylhomocysteine catabolic process
S-adenosylmethionine cycle
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
chronic inflammatory response to antigenic stimulus
circadian sleep/wake cycle
homocysteine biosynthetic process
methylation
one-carbon metabolic process
response to hypoxia
response to nutrient
S-adenosylhomocysteine catabolic process
S-adenosylmethionine cycle
selenium compound metabolic process
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- adenosylhomocysteinase activity
adenyl nucleotide binding
NAD binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
melanosome
neuron projection
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Hydrolase
NAD
One-carbon metabolism
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- Q6AI12; Q92624; Q9BV19