Names & Taxonomy
- Uniprot ID:
- P23458
- Entry Name:
- JAK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
- Gene Names:
- JAK1 JAK1A JAK1B
- Gene Names Primary:
- JAK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1154
- Sequence:
- MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Function
- Function:
- Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 1003 1003 Proton acceptor.
- Cross Reference Drug Bank:
- DB08877 DB08895
- Gene Ontology Go:
- cytoplasm
cytoskeleton
cytosol
endomembrane system
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
nucleus
ATP binding
growth hormone receptor binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein phosphatase binding
protein tyrosine kinase activity
receptor binding
ubiquitin protein ligase binding
activation of MAPKK activity
axon guidance
cell differentiation
cell migration
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
interleukin-2-mediated signaling pathway
intracellular signal transduction
MAPK cascade
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of sprouting angiogenesis
protein phosphorylation
Ras protein signal transduction
regulation of cell proliferation
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
response to antibiotic
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
type I interferon signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cell differentiation
cell migration
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
interleukin-2-mediated signaling pathway
intracellular signal transduction
MAPK cascade
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of sprouting angiogenesis
protein phosphorylation
Ras protein signal transduction
regulation of cell proliferation
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
response to antibiotic
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
type I interferon signaling pathway
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
growth hormone receptor binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein phosphatase binding
protein tyrosine kinase activity
receptor binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
cytosol
endomembrane system
extrinsic component of cytoplasmic side of plasma membrane
focal adhesion
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Kinase
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH2 domain
Transferase
Tyrosine-protein kinase - Interacts With:
- P04626; P48551