Names & Taxonomy
- Uniprot ID:
- P23142
- Entry Name:
- FBLN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fibulin-1 (FIBL-1)
- Gene Names:
- FBLN1 PP213
- Gene Names Orf:
- PP213
- Gene Names Primary:
- FBLN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 703
- Sequence:
- MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
- Gene Ontology Go:
- basement membrane
elastic fiber
extracellular exosome
extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
extracellular matrix structural constituent
fibrinogen binding
fibronectin binding
identical protein binding
integrin binding
peptidase activator activity
protein C-terminus binding
protein complex binding
blood coagulation, fibrin clot formation
embryo implantation
extracellular matrix organization
negative regulation of cell adhesion
negative regulation of cell motility
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
negative regulation of stem cell proliferation
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of transformation of host cell by virus
negative regulation of transforming growth factor-beta secretion
positive regulation of fibroblast proliferation
positive regulation of gene expression
positive regulation of substrate-dependent cell migration, cell attachment to substrate
viral process - Gene Ontology Biological Process:
- blood coagulation, fibrin clot formation
embryo implantation
extracellular matrix organization
negative regulation of cell adhesion
negative regulation of cell motility
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
negative regulation of stem cell proliferation
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of transformation of host cell by virus
negative regulation of transforming growth factor-beta secretion
positive regulation of fibroblast proliferation
positive regulation of gene expression
positive regulation of substrate-dependent cell migration, cell attachment to substrate
viral process - Gene Ontology Molecular Function:
- calcium ion binding
extracellular matrix structural constituent
fibrinogen binding
fibronectin binding
identical protein binding
integrin binding
peptidase activator activity
protein complex binding
protein C-terminus binding - Gene Ontology Cellular Component:
- basement membrane
elastic fiber
extracellular exosome
extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Calcium
Chromosomal rearrangement
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Host-virus interaction
Polymorphism
Reference proteome
Repeat
Secreted
Signal