Names & Taxonomy
- Uniprot ID:
- P23109
- Entry Name:
- AMPD1_HUMAN
- Status:
- reviewed
- Protein Names:
- AMP deaminase 1 (EC 3.5.4.6) (AMP deaminase isoform M) (Myoadenylate deaminase)
- Gene Names:
- AMPD1
- Gene Names Primary:
- AMPD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 780
- Sequence:
- MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
- Proteomes:
- UP000005640
Function
- Function:
- AMP deaminase plays a critical role in energy metabolism.
- Pathway:
- Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
- Catalytic Activity:
- AMP + H(2)O = IMP + NH(3).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 627 627 Proton acceptor.
- Cross Reference Drug Bank:
- DB00131
- Gene Ontology Go:
- cytosol
AMP deaminase activity
metal ion binding
IMP salvage
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine-containing compound salvage
response to organic substance
small molecule metabolic process - Gene Ontology Biological Process:
- IMP salvage
nucleobase-containing small molecule metabolic process
purine-containing compound salvage
purine nucleobase metabolic process
response to organic substance
small molecule metabolic process - Gene Ontology Molecular Function:
- AMP deaminase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Hydrolase
Metal-binding
Nucleotide metabolism
Phosphoprotein
Polymorphism
Reference proteome
Zinc