Names & Taxonomy
- Uniprot ID:
- P22894
- Entry Name:
- MMP8_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
- Gene Names:
- MMP8 CLG1
- Gene Names Primary:
- MMP8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic granule. Secreted, extracellular space, extracellular matrix
Function
- Function:
- Can degrade fibrillar type I, II, and III collagens.
- Catalytic Activity:
- Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 3 Ca(2+) ions per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
- Enzyme Regulation:
- ENZYME REGULATION: Cannot be activated without removal of the activation peptide.
- Active Site:
- ACT_SITE 218 218
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
serine-type endopeptidase activity
zinc ion binding
collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
proteolysis - Gene Ontology Biological Process:
- collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
proteolysis - Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
serine-type endopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen