Names & Taxonomy

Uniprot ID:
P22894
Entry Name:
MMP8_HUMAN
Status:
reviewed
Protein Names:
Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
Gene Names:
MMP8 CLG1
Gene Names Primary:
MMP8
Organism:
Homo sapiens (Human)

Structure

Length:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic granule. Secreted, extracellular space, extracellular matrix

Function

Function:
Can degrade fibrillar type I, II, and III collagens.
Catalytic Activity:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 3 Ca(2+) ions per subunit.;; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
Enzyme Regulation:
ENZYME REGULATION: Cannot be activated without removal of the activation peptide.
Active Site:
ACT_SITE 218 218
Cross Reference Drug Bank:
DB00786
Gene Ontology Go:
extracellular region
extracellular space
proteinaceous extracellular matrix
calcium ion binding
metalloendopeptidase activity
serine-type endopeptidase activity
zinc ion binding
collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
proteolysis
Gene Ontology Biological Process:
collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
proteolysis
Gene Ontology Molecular Function:
calcium ion binding
metalloendopeptidase activity
serine-type endopeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
extracellular space
proteinaceous extracellular matrix
Keywords:
3D-structure
Calcium
Collagen degradation
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Publication

PubMed ID:
2164002 15489334 2159879 1662606 2176876 2169256 1330697 8137810 8307185 7656015 9249047 9655333