Names & Taxonomy

Uniprot ID:
P22749
Entry Name:
GNLY_HUMAN
Status:
reviewed
Protein Names:
Granulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519)
Gene Names:
GNLY LAG2 NKG5 TLA519
Gene Names Primary:
GNLY
Organism:
Homo sapiens (Human)

Structure

Length:
145
Sequence:
MATWALLLLAAMLLGNPGLVFSRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

Function

Function:
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Gene Ontology Go:
extracellular space
cellular defense response
defense response to bacterium
defense response to fungus
killing of cells of other organism
Gene Ontology Biological Process:
cellular defense response
defense response to bacterium
defense response to fungus
killing of cells of other organism
Gene Ontology Cellular Component:
extracellular space
Keywords:
3D-structure
Alternative splicing
Antibiotic
Antimicrobial
Complete proteome
Disulfide bond
Fungicide
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2434598 2212946 8423048 15489334 10644038 9756476 10449094 12488100