Names & Taxonomy
- Uniprot ID:
- P22749
- Entry Name:
- GNLY_HUMAN
- Status:
- reviewed
- Protein Names:
- Granulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519)
- Gene Names:
- GNLY LAG2 NKG5 TLA519
- Gene Names Primary:
- GNLY
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 145
- Sequence:
- MATWALLLLAAMLLGNPGLVFSRLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Function
- Function:
- Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
- Gene Ontology Go:
- extracellular space
cellular defense response
defense response to bacterium
defense response to fungus
killing of cells of other organism - Gene Ontology Biological Process:
- cellular defense response
defense response to bacterium
defense response to fungus
killing of cells of other organism - Gene Ontology Cellular Component:
- extracellular space
- Keywords:
- 3D-structure
Alternative splicing
Antibiotic
Antimicrobial
Complete proteome
Disulfide bond
Fungicide
Polymorphism
Reference proteome
Secreted
Signal