Names & Taxonomy
- Uniprot ID:
- P22735
- Entry Name:
- TGM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)
- Gene Names:
- TGM1 KTG
- Gene Names Primary:
- TGM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 817
- Sequence:
- MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Lipid-anchor.
Function
- Function:
- Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141).
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
- Active Site:
- ACT_SITE 377 377
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cornified envelope
extracellular exosome
intrinsic component of membrane
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
cell envelope organization
cellular protein modification process
keratinization
keratinocyte differentiation
peptide cross-linking
positive regulation of cell cycle
positive regulation of keratinocyte proliferation - Gene Ontology Biological Process:
- cell envelope organization
cellular protein modification process
keratinization
keratinocyte differentiation
peptide cross-linking
positive regulation of cell cycle
positive regulation of keratinocyte proliferation - Gene Ontology Molecular Function:
- metal ion binding
protein-glutamine gamma-glutamyltransferase activity - Gene Ontology Cellular Component:
- cornified envelope
extracellular exosome
intrinsic component of membrane - Keywords:
- 3D-structure
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Disease mutation
Ichthyosis
Keratinization
Lipoprotein
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase