Names & Taxonomy
- Uniprot ID:
- P22570
- Entry Name:
- ADRO_HUMAN
- Status:
- reviewed
- Protein Names:
- NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)
- Gene Names:
- FDXR ADXR
- Gene Names Primary:
- FDXR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 491
- Sequence:
- MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVPELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
- Pathway:
- Steroid metabolism; cholesterol metabolism.
- Catalytic Activity:
- 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
ferredoxin-NADP+ reductase activity
NADPH-adrenodoxin reductase activity
C21-steroid hormone biosynthetic process
cholesterol metabolic process
generation of precursor metabolites and energy
oxidation-reduction process
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- C21-steroid hormone biosynthetic process
cholesterol metabolic process
generation of precursor metabolites and energy
oxidation-reduction process
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- ferredoxin-NADP+ reductase activity
NADPH-adrenodoxin reductase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Alternative splicing
Cholesterol metabolism
Complete proteome
Electron transport
FAD
Flavoprotein
Lipid metabolism
Mitochondrion
NADP
Oxidoreductase
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transit peptide
Transport - Interacts With:
- P49789