Names & Taxonomy
- Uniprot ID:
- P22352
- Entry Name:
- GPX3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)
- Gene Names:
- GPX3 GPXP
- Gene Names Primary:
- GPX3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 226
- Sequence:
- MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
- Catalytic Activity:
- 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
- Active Site:
- ACT_SITE 73 73
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
glutathione peroxidase activity
selenium binding
transcription factor binding
cellular oxidant detoxification
hydrogen peroxide catabolic process
protein homotetramerization
response to lipid hydroperoxide
response to reactive oxygen species - Gene Ontology Biological Process:
- cellular oxidant detoxification
hydrogen peroxide catabolic process
protein homotetramerization
response to lipid hydroperoxide
response to reactive oxygen species - Gene Ontology Molecular Function:
- glutathione peroxidase activity
selenium binding
transcription factor binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Secreted
Selenocysteine
Signal - Interacts With:
- Q9UMX0-2