Names & Taxonomy
- Uniprot ID:
- P22309
- Entry Name:
- UD11_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-1 (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-A) (UGT-1A) (UGT1A) (UDP-glucuronosyltransferase 1A1)
- Gene Names:
- UGT1A1 GNT1 UGT1
- Gene Names Primary:
- UGT1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 533
- Sequence:
- MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Microsome
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.26 uM for bilirubin
- Cross Reference Drug Bank:
- DB01048 DB00316 DB00173 DB01076 DB06626 DB00586 DB08930 DB06210 DB00530 DB00783 DB00773 DB00973 DB04953 DB01544 DB00712 DB01095 DB01050 DB05039 DB00328 DB00762 DB00678 DB00227 DB00295 DB00688 DB01024 DB00704 DB00788 DB04868 DB06589 DB00818 DB06817 DB08896 DB01045 DB00641 DB00398 DB00870 DB01420
- Gene Ontology Go:
- cytochrome complex
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum membrane
integral component of plasma membrane
enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding
steroid binding
acute-phase response
bilirubin conjugation
biphenyl catabolic process
cellular glucuronidation
cellular response to ethanol
cellular response to glucocorticoid stimulus
digestion
drug metabolic process
estrogen metabolic process
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
heme catabolic process
heterocycle metabolic process
liver development
negative regulation of catalytic activity
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
negative regulation of steroid metabolic process
organ regeneration
porphyrin-containing compound metabolic process
response to drug
response to lipopolysaccharide
response to nutrient
response to starvation
retinoic acid metabolic process
small molecule metabolic process
steroid metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process - Gene Ontology Biological Process:
- acute-phase response
bilirubin conjugation
biphenyl catabolic process
cellular glucuronidation
cellular response to ethanol
cellular response to glucocorticoid stimulus
digestion
drug metabolic process
estrogen metabolic process
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
heme catabolic process
heterocycle metabolic process
liver development
negative regulation of catalytic activity
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
negative regulation of steroid metabolic process
organ regeneration
porphyrin-containing compound metabolic process
response to drug
response to lipopolysaccharide
response to nutrient
response to starvation
retinoic acid metabolic process
small molecule metabolic process
steroid metabolic process
xenobiotic glucuronidation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding
steroid binding - Gene Ontology Cellular Component:
- cytochrome complex
endoplasmic reticulum
endoplasmic reticulum chaperone complex
endoplasmic reticulum membrane
integral component of plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 1898728 1339448 11434514 15815621 12475965 17187418 18004206 18004212 19545173 19830808 19414484 19159218 20610558 24275569 1634050 8280139 8276413 8226884 7989045 7906695 7989595 7715297 8706880 9639672 9621515 9627603 11013440 11061796 11370628 12402338 12139570 14550264 15712364 17229650 23992562 23099197