Names & Taxonomy
- Uniprot ID:
- P22234
- Entry Name:
- PUR6_HUMAN
- Status:
- reviewed
- Protein Names:
- Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]
- Gene Names:
- PAICS ADE2 AIRC PAIS
- Gene Names Primary:
- PAICS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 425
- Sequence:
- MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL
- Proteomes:
- UP000005640
Function
- Pathway:
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.; Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
- Catalytic Activity:
- ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
- Active Site:
- ACT_SITE 101 101 For SAICAR synthetase activity.
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
ATP binding
identical protein binding
phosphoribosylaminoimidazole carboxylase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
'de novo' IMP biosynthetic process
adenine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- 'de novo' IMP biosynthetic process
adenine biosynthetic process
nucleobase-containing small molecule metabolic process
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
phosphoribosylaminoimidazole carboxylase activity
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Decarboxylase
Direct protein sequencing
Ligase
Lyase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Polymorphism
Purine biosynthesis
Reference proteome - Interacts With:
- Itself; P51116; Q969R5; Q6ZVK8