Names & Taxonomy

Uniprot ID:
P21980
Entry Name:
TGM2_HUMAN
Status:
reviewed
Protein Names:
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2)
Gene Names:
TGM2
Gene Names Primary:
TGM2
Organism:
Homo sapiens (Human)

Structure

Length:
687
Sequence:
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA
Proteomes:
UP000005640

Function

Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Catalytic Activity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 277 277
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytosol
endoplasmic reticulum
extracellular exosome
focal adhesion
intrinsic component of plasma membrane
mitochondrion
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
apoptotic cell clearance
branching involved in salivary gland morphogenesis
negative regulation of endoplasmic reticulum calcium ion concentration
peptide cross-linking
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
salivary gland cavitation
Gene Ontology Biological Process:
apoptotic cell clearance
branching involved in salivary gland morphogenesis
negative regulation of endoplasmic reticulum calcium ion concentration
peptide cross-linking
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
salivary gland cavitation
Gene Ontology Molecular Function:
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
Gene Ontology Cellular Component:
cytosol
endoplasmic reticulum
extracellular exosome
focal adhesion
intrinsic component of plasma membrane
mitochondrion
Keywords:
3D-structure
Acetylation
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Interacts With:
Q12802; P39060; P02751; Q04206; P40337

Publication

PubMed ID:
1670766 1358880 8611626 14702039 11780052 15489334 21269460 22814378 24275569 18092889 16959974 17939176