Names & Taxonomy
- Uniprot ID:
- P21980
- Entry Name:
- TGM2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2)
- Gene Names:
- TGM2
- Gene Names Primary:
- TGM2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 687
- Sequence:
- MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 277 277
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytosol
endoplasmic reticulum
extracellular exosome
focal adhesion
intrinsic component of plasma membrane
mitochondrion
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
apoptotic cell clearance
branching involved in salivary gland morphogenesis
negative regulation of endoplasmic reticulum calcium ion concentration
peptide cross-linking
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
salivary gland cavitation - Gene Ontology Biological Process:
- apoptotic cell clearance
branching involved in salivary gland morphogenesis
negative regulation of endoplasmic reticulum calcium ion concentration
peptide cross-linking
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of mitochondrial calcium ion concentration
salivary gland cavitation - Gene Ontology Molecular Function:
- metal ion binding
protein-glutamine gamma-glutamyltransferase activity - Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum
extracellular exosome
focal adhesion
intrinsic component of plasma membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q12802; P39060; P02751; Q04206; P40337