Names & Taxonomy

Uniprot ID:
P21917
Entry Name:
DRD4_HUMAN
Status:
reviewed
Protein Names:
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
Gene Names:
DRD4
Gene Names Primary:
DRD4
Organism:
Homo sapiens (Human)

Structure

Length:
467
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Cross Reference Drug Bank:
DB00543 DB00714 DB01238 DB06216 DB01200 DB00248 DB00477 DB00363 DB00988 DB04908 DB04946 DB01235 DB00589 DB00408 DB01403 DB00334 DB01267 DB01186 DB00413 DB00420 DB00777 DB01224 DB00409 DB00734 DB00268 DB05271 DB00246
Gene Ontology Go:
cell cortex
dendritic spine
integral component of plasma membrane
membrane
neuronal cell body
plasma membrane
terminal bouton
vesicle membrane
dopamine binding
dopamine neurotransmitter receptor activity
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity, coupled via Gs
drug binding
identical protein binding
potassium channel regulator activity
SH3 domain binding
activation of MAPK activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adult locomotory behavior
arachidonic acid secretion
behavioral fear response
behavioral response to cocaine
behavioral response to ethanol
cellular calcium ion homeostasis
circadian rhythm
dopamine metabolic process
dopamine receptor signaling pathway
fear response
inhibitory postsynaptic potential
negative regulation of adenylate cyclase activity
negative regulation of cAMP biosynthetic process
negative regulation of protein secretion
negative regulation of voltage-gated calcium channel activity
olfactory learning
photoperiodism
positive regulation of dopamine uptake involved in synaptic transmission
positive regulation of excitatory postsynaptic potential
positive regulation of kinase activity
positive regulation of penile erection
positive regulation of sodium:proton antiporter activity
regulation of calcium-mediated signaling
regulation of circadian rhythm
regulation of dopamine metabolic process
regulation of neurotransmitter secretion
response to amphetamine
response to histamine
response to steroid hormone
retina development in camera-type eye
short-term memory
social behavior
synaptic transmission, dopaminergic
Gene Ontology Biological Process:
activation of MAPK activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
adult locomotory behavior
arachidonic acid secretion
behavioral fear response
behavioral response to cocaine
behavioral response to ethanol
cellular calcium ion homeostasis
circadian rhythm
dopamine metabolic process
dopamine receptor signaling pathway
fear response
inhibitory postsynaptic potential
negative regulation of adenylate cyclase activity
negative regulation of cAMP biosynthetic process
negative regulation of protein secretion
negative regulation of voltage-gated calcium channel activity
olfactory learning
photoperiodism
positive regulation of dopamine uptake involved in synaptic transmission
positive regulation of excitatory postsynaptic potential
positive regulation of kinase activity
positive regulation of penile erection
positive regulation of sodium:proton antiporter activity
regulation of calcium-mediated signaling
regulation of circadian rhythm
regulation of dopamine metabolic process
regulation of neurotransmitter secretion
response to amphetamine
response to histamine
response to steroid hormone
retina development in camera-type eye
short-term memory
social behavior
synaptic transmission, dopaminergic
Gene Ontology Molecular Function:
dopamine binding
dopamine neurotransmitter receptor activity
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity, coupled via Gs
drug binding
identical protein binding
potassium channel regulator activity
SH3 domain binding
Gene Ontology Cellular Component:
cell cortex
dendritic spine
integral component of plasma membrane
membrane
neuronal cell body
plasma membrane
terminal bouton
vesicle membrane
Keywords:
Biological rhythms
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation
Interacts With:
Itself

Publication

PubMed ID:
1319557 1840645 16554811 8353495 8078498 12142540 18303015 20836733 20100572 21184734 1358063 7726213