Names & Taxonomy
- Uniprot ID:
- P21860
- Entry Name:
- ERBB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
- Gene Names:
- ERBB3 HER3
- Gene Names Primary:
- ERBB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1342
- Sequence:
- MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
Function
- Function:
- Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 834 834 Proton acceptor.
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
extracellular space
integral component of plasma membrane
intracellular
lateral plasma membrane
plasma membrane
receptor complex
ATP binding
growth factor binding
identical protein binding
protein heterodimerization activity
protein homodimerization activity
protein kinase activity
protein tyrosine kinase activator activity
transmembrane signaling receptor activity
activation of MAPKK activity
axon guidance
cranial nerve development
endocardial cushion development
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
heart development
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of cell adhesion
negative regulation of neuron apoptotic process
negative regulation of secretion
negative regulation of signal transduction
neuron apoptotic process
neurotrophin TRK receptor signaling pathway
peripheral nervous system development
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein tyrosine kinase activity
Ras protein signal transduction
regulation of cell proliferation
Schwann cell differentiation
signal transduction
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
wound healing - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cranial nerve development
endocardial cushion development
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
heart development
innate immune response
insulin receptor signaling pathway
MAPK cascade
negative regulation of cell adhesion
negative regulation of neuron apoptotic process
negative regulation of secretion
negative regulation of signal transduction
neuron apoptotic process
neurotrophin TRK receptor signaling pathway
peripheral nervous system development
phosphatidylinositol 3-kinase signaling
phosphatidylinositol-mediated signaling
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein tyrosine kinase activity
Ras protein signal transduction
regulation of cell proliferation
Schwann cell differentiation
signal transduction
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
wound healing - Gene Ontology Molecular Function:
- ATP binding
growth factor binding
identical protein binding
protein heterodimerization activity
protein homodimerization activity
protein kinase activity
protein tyrosine kinase activator activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
extracellular space
integral component of plasma membrane
intracellular
lateral plasma membrane
plasma membrane
receptor complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase - Interacts With:
- Itself; P42684; P46108; P46109; P00533; P04626; Q15303; P62993; Q14451; P08631; P08238; O43639; Q02297-7; P42336; P27986; O00459; Q92569; P19174; P20936; Q9UQQ2; P29353; Q92529; P12931; P43405; Q63HR2; Q68CZ2