Names & Taxonomy

Uniprot ID:
P21673
Entry Name:
SAT1_HUMAN
Status:
reviewed
Protein Names:
Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)
Gene Names:
SAT1 SAT
Gene Names Primary:
SAT1
Organism:
Homo sapiens (Human)

Structure

Length:
171
Sequence:
MAKFVIRPATAADCSDILRLIKELAKYEYMEEQVILTEKDLLEDGFGEHPFYHCLVAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMRCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMATEE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
Pathway:
Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.
Catalytic Activity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.8 uM for acetyl-coenzyme A
Cross Reference Drug Bank:
DB00127
Gene Ontology Go:
cytosol
intracellular
diamine N-acetyltransferase activity
angiogenesis
cellular nitrogen compound metabolic process
polyamine biosynthetic process
polyamine metabolic process
putrescine catabolic process
regulation of cell proliferation
small molecule metabolic process
Gene Ontology Biological Process:
angiogenesis
cellular nitrogen compound metabolic process
polyamine biosynthetic process
polyamine metabolic process
putrescine catabolic process
regulation of cell proliferation
small molecule metabolic process
Gene Ontology Molecular Function:
diamine N-acetyltransferase activity
Gene Ontology Cellular Component:
cytosol
intracellular
Keywords:
3D-structure
Acyltransferase
Complete proteome
Cytoplasm
Direct protein sequencing
Reference proteome
Transferase
Interacts With:
P17482; Q9BQ70

Publication

PubMed ID:
1985966 1652956 1417826 8573111 15489334 2241897 16455797 17516632 16544326 9341865 12215835