Names & Taxonomy
- Uniprot ID:
- P21589
- Entry Name:
- 5NTD_HUMAN
- Status:
- reviewed
- Protein Names:
- 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73)
- Gene Names:
- NT5E NT5 NTE
- Gene Names Primary:
- NT5E
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 574
- Sequence:
- MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor.
Function
- Function:
- Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
- Catalytic Activity:
- A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00987 DB00806
- Gene Ontology Go:
- anchored component of membrane
cell surface
cytoplasm
extracellular exosome
membrane
plasma membrane
synaptic membrane
5'-nucleotidase activity
ferrous iron binding
nucleotide binding
adenosine biosynthetic process
AMP catabolic process
brain development
DNA metabolic process
leukocyte cell-cell adhesion
negative regulation of inflammatory response
nucleobase-containing small molecule metabolic process
positive regulation of lipid biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine nucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
response to aluminum ion
small molecule metabolic process - Gene Ontology Biological Process:
- adenosine biosynthetic process
AMP catabolic process
brain development
DNA metabolic process
leukocyte cell-cell adhesion
negative regulation of inflammatory response
nucleobase-containing small molecule metabolic process
positive regulation of lipid biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine nucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
response to aluminum ion
small molecule metabolic process - Gene Ontology Molecular Function:
- 5'-nucleotidase activity
ferrous iron binding
nucleotide binding - Gene Ontology Cellular Component:
- anchored component of membrane
cell surface
cytoplasm
extracellular exosome
membrane
plasma membrane
synaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
GPI-anchor
Glycoprotein
Hydrolase
Lipoprotein
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Signal
Zinc