Names & Taxonomy
- Uniprot ID:
- P21399
- Entry Name:
- ACOC_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)
- Gene Names:
- ACO1 IREB1
- Gene Names Primary:
- ACO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 889
- Sequence:
- MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
- Catalytic Activity:
- Citrate = isocitrate.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883;
- Cross Reference Drug Bank:
- DB06757
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
Golgi apparatus
mitochondrion
4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding
metal ion binding
RNA binding
cellular iron ion homeostasis
citrate metabolic process
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular iron ion homeostasis
citrate metabolic process
intestinal absorption
post-embryonic development
regulation of translation
response to iron(II) ion
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
aconitate hydratase activity
iron-responsive element binding
metal ion binding
RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
Golgi apparatus
mitochondrion - Keywords:
- 3D-structure
4Fe-4S
Complete proteome
Cytoplasm
Direct protein sequencing
Iron
Iron-sulfur
Lyase
Metal-binding
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Tricarboxylic acid cycle - Interacts With:
- P20929; Q13326