Names & Taxonomy
- Uniprot ID:
- P20908
- Entry Name:
- CO5A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(V) chain
- Gene Names:
- COL5A1
- Gene Names Primary:
- COL5A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1838
- Sequence:
- MDVHTRWKARSALRPGAPLLPPLLLLLLWAPPPSRAAQPADLLKVLDFHNLPDGITKTTGFCATRRSSKGPDVAYRVTKDAQLSAPTKQLYPASAFPEDFSILTTVKAKKGSQAFLVSIYNEQGIQQIGLELGRSPVFLYEDHTGKPGPEDYPLFRGINLSDGKWHRIALSVHKKNVTLILDCKKKTTKFLDRSDHPMIDINGIIVFGTRILDEEVFEGDIQQLLFVSDHRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYTEGDGEGETYYYEYPYYEDPEDLGKEPTPSKKPVEAAKETTEVPEELTPTPTEAAPMPETSEGAGKEEDVGIGDYDYVPSEDYYTPSPYDDLTYGEGEENPDQPTDPGAGAEIPTSTADTSNSSNPAPPPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPSEIGPGMPANQDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQDAATGSYDKALRFLGSNDEEMSYDNNPYIRALVDGCATKKGYQKTVLEIDTPKVEQVPIVDIMFNDFGEASQKFGFEVGPACFMG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
- Gene Ontology Go:
- basement membrane
collagen type V trimer
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region
extracellular matrix structural constituent
heparin binding
integrin binding
metal ion binding
platelet-derived growth factor binding
proteoglycan binding
axon guidance
blood vessel development
cell adhesion
cell migration
collagen biosynthetic process
collagen catabolic process
collagen fibril organization
extracellular fibril organization
extracellular matrix disassembly
extracellular matrix organization
eye morphogenesis
heart morphogenesis
integrin biosynthetic process
negative regulation of endodermal cell differentiation
regulation of cellular component organization
skin development
tendon development
wound healing, spreading of epidermal cells - Gene Ontology Biological Process:
- axon guidance
blood vessel development
cell adhesion
cell migration
collagen biosynthetic process
collagen catabolic process
collagen fibril organization
extracellular fibril organization
extracellular matrix disassembly
extracellular matrix organization
eye morphogenesis
heart morphogenesis
integrin biosynthetic process
negative regulation of endodermal cell differentiation
regulation of cellular component organization
skin development
tendon development
wound healing, spreading of epidermal cells - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
heparin binding
integrin binding
metal ion binding
platelet-derived growth factor binding
proteoglycan binding - Gene Ontology Cellular Component:
- basement membrane
collagen type V trimer
endoplasmic reticulum lumen
extracellular exosome
extracellular matrix
extracellular region - Keywords:
- 3D-structure
Calcium
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Ehlers-Danlos syndrome
Extracellular matrix
Heparin-binding
Hydroxylation
Metal-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Sulfation