Names & Taxonomy

Uniprot ID:
P20813
Entry Name:
CP2B6_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)
Gene Names:
CYP2B6
Gene Names Primary:
CYP2B6
Organism:
Homo sapiens (Human)

Structure

Length:
491
Sequence:
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Catalytic Activity:
1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=360 uM for 1,4-cineole
Cross Reference Drug Bank:
DB00321 DB00381 DB00701 DB01435 DB06413 DB06697 DB01076 DB00972 DB00865 DB06770 DB04794 DB00835 DB01156 DB00564 DB00748 DB00169 DB00568 DB00604 DB00515 DB00215 DB00349 DB00636 DB00758 DB01559 DB00257 DB01394 DB00531 DB01151 DB01234 DB00514 DB00829 DB00586 DB01075 DB01184 DB00997 DB00625 DB08899 DB00751 DB00199 DB00655 DB00898 DB01466 DB04841 DB01544 DB00472 DB01095 DB00176 DB01320 DB01159 DB09054 DB01181 DB00458 DB00762 DB00753 DB01167 DB09570 DB01221 DB06738 DB01026 DB00281 DB00836 DB01601 DB04871 DB00772 DB01043 DB00333 DB00763 DB01028 DB00849 DB06710 DB00379 DB06148 DB01110 DB00683 DB00745 DB00220 DB00238 DB00622 DB00184 DB01115 DB04868 DB00435 DB09074 DB01173 DB04938 DB00715 DB01074 DB04930 DB00850 DB00454 DB01174 DB00252 DB06209 DB00794 DB01069 DB00818 DB00908 DB00481 DB08896 DB01045 DB08864 DB00503 DB00296 DB00778 DB01037 DB01104 DB01236 DB00641 DB00398 DB06729 DB01138 DB00675 DB00231 DB00624 DB04572 DB00208 DB00193 DB00755 DB00313 DB00285 DB00661 DB09068
Gene Ontology Go:
endoplasmic reticulum membrane
arachidonic acid epoxygenase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
steroid hydroxylase activity
cellular ketone metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular ketone metabolic process
drug metabolic process
epoxygenase P450 pathway
exogenous drug catabolic process
oxidation-reduction process
small molecule metabolic process
steroid metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
arachidonic acid epoxygenase activity
heme binding
iron ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
steroid hydroxylase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
2573390 14702039 15057824 2813061 10768437 11695850 24275569 20061448 21875942 22909231 15622315 20639527 20860463 11243870 11470993 12642465 12721789 14551287 15190123 15469410