Names & Taxonomy

Uniprot ID:
P20701
Entry Name:
ITAL_HUMAN
Status:
reviewed
Protein Names:
Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
Gene Names:
ITGAL CD11A
Gene Names Primary:
ITGAL
Organism:
Homo sapiens (Human)

Structure

Length:
1170
Sequence:
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Cross Reference Drug Bank:
DB00098 DB00095 DB00227
Gene Ontology Go:
cell surface
extracellular exosome
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane
cell adhesion molecule binding
ICAM-3 receptor activity
metal ion binding
blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
movement of cell or subcellular component
receptor clustering
regulation of immune response
signal transduction
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Gene Ontology Biological Process:
blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
movement of cell or subcellular component
receptor clustering
regulation of immune response
signal transduction
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Gene Ontology Molecular Function:
cell adhesion molecule binding
ICAM-3 receptor activity
metal ion binding
Gene Ontology Cellular Component:
cell surface
extracellular exosome
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q9WMX2; P08575

Publication

PubMed ID:
2537322 10493829 15616553 15489334 8099450 8103515 8097887 19349973 7479767 8805579 10493852 12526797