Names & Taxonomy
- Uniprot ID:
- P20701
- Entry Name:
- ITAL_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
- Gene Names:
- ITGAL CD11A
- Gene Names Primary:
- ITGAL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1170
- Sequence:
- MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
- Cross Reference Drug Bank:
- DB00098 DB00095 DB00227
- Gene Ontology Go:
- cell surface
extracellular exosome
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane
cell adhesion molecule binding
ICAM-3 receptor activity
metal ion binding
blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
movement of cell or subcellular component
receptor clustering
regulation of immune response
signal transduction
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell - Gene Ontology Biological Process:
- blood coagulation
cell adhesion
cell-matrix adhesion
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
inflammatory response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
movement of cell or subcellular component
receptor clustering
regulation of immune response
signal transduction
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell - Gene Ontology Molecular Function:
- cell adhesion molecule binding
ICAM-3 receptor activity
metal ion binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9WMX2; P08575