Names & Taxonomy

Uniprot ID:
P20339
Entry Name:
RAB5A_HUMAN
Status:
reviewed
Protein Names:
Ras-related protein Rab-5A
Gene Names:
RAB5A RAB5
Gene Names Primary:
RAB5A
Organism:
Homo sapiens (Human)

Structure

Length:
215
Sequence:
MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Enzyme Regulation:
ENZYME REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
Gene Ontology Go:
actin cytoskeleton
axon
axon terminus
cytoplasm
cytoplasmic side of early endosome membrane
cytosol
dendrite
early endosome
endocytic vesicle
endosome
endosome membrane
extracellular exosome
melanosome
membrane raft
neuronal cell body
phagocytic vesicle
plasma membrane
ruffle
somatodendritic compartment
synaptic vesicle
terminal bouton
GDP binding
GTP binding
GTPase activity
blood coagulation
early endosome to late endosome transport
endocytosis
positive regulation of exocytosis
protein transport
receptor internalization involved in canonical Wnt signaling pathway
regulation of autophagosome assembly
regulation of endocytosis
regulation of endosome size
regulation of filopodium assembly
regulation of synaptic vesicle exocytosis
small GTPase mediated signal transduction
synaptic vesicle recycling
Gene Ontology Biological Process:
blood coagulation
early endosome to late endosome transport
endocytosis
positive regulation of exocytosis
protein transport
receptor internalization involved in canonical Wnt signaling pathway
regulation of autophagosome assembly
regulation of endocytosis
regulation of endosome size
regulation of filopodium assembly
regulation of synaptic vesicle exocytosis
small GTPase mediated signal transduction
synaptic vesicle recycling
Gene Ontology Molecular Function:
GDP binding
GTPase activity
GTP binding
Gene Ontology Cellular Component:
actin cytoskeleton
axon
axon terminus
cytoplasm
cytoplasmic side of early endosome membrane
cytosol
dendrite
early endosome
endocytic vesicle
endosome
endosome membrane
extracellular exosome
melanosome
membrane raft
neuronal cell body
phagocytic vesicle
plasma membrane
ruffle
somatodendritic compartment
synaptic vesicle
terminal bouton
Keywords:
3D-structure
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Endocytosis
Endosome
GTP-binding
Lipoprotein
Membrane
Nucleotide-binding
Phagocytosis
Prenylation
Protein transport
Reference proteome
Transport
Interacts With:
Q96Q42; Q9UKG1; Q15075; Q01968; P23727

Publication

PubMed ID:
2501306 7991565 14702039 16641997 15489334 10491193 10818110 11062261 11703925 15388334 14617813 14978216 16034420 16410077 17081065 18669648 21269460 22660413 23815289 25869668 25944712 12433916 14684892 15378032 20534488