Names & Taxonomy
- Uniprot ID:
- P20138
- Entry Name:
- CD33_HUMAN
- Status:
- reviewed
- Protein Names:
- Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
- Gene Names:
- CD33 SIGLEC3
- Gene Names Primary:
- CD33
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 364
- Sequence:
- MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
- Cross Reference Drug Bank:
- DB00056
- Gene Ontology Go:
- external side of plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
carbohydrate binding
receptor activity
cell adhesion
cell-cell signaling
negative regulation of cell proliferation
regulation of immune response
signal transduction - Gene Ontology Biological Process:
- cell adhesion
cell-cell signaling
negative regulation of cell proliferation
regulation of immune response
signal transduction - Gene Ontology Molecular Function:
- carbohydrate binding
receptor activity - Gene Ontology Cellular Component:
- external side of plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lectin
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q15323; Q6A162; Q06124; P29350