Names & Taxonomy
- Uniprot ID:
- P20132
- Entry Name:
- SDHL_HUMAN
- Status:
- reviewed
- Protein Names:
- L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19)
- Gene Names:
- SDS SDH
- Gene Names Primary:
- SDS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 328
- Sequence:
- MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Pathway:
- Carbohydrate biosynthesis; gluconeogenesis.
- Catalytic Activity:
- L-serine = pyruvate + NH(3).
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=23 mM for serine
- Cross Reference Drug Bank:
- DB00133
- Gene Ontology Go:
- cytoplasm
mitochondrion
L-serine ammonia-lyase activity
L-threonine ammonia-lyase activity
protein homodimerization activity
pyridoxal phosphate binding
gluconeogenesis
L-serine catabolic process
pyruvate biosynthetic process - Gene Ontology Biological Process:
- gluconeogenesis
L-serine catabolic process
pyruvate biosynthetic process - Gene Ontology Molecular Function:
- L-serine ammonia-lyase activity
L-threonine ammonia-lyase activity
protein homodimerization activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrion - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Gluconeogenesis
Lyase
Pyridoxal phosphate
Reference proteome