Names & Taxonomy
- Uniprot ID:
- P19883
- Entry Name:
- FST_HUMAN
- Status:
- reviewed
- Protein Names:
- Follistatin (FS) (Activin-binding protein)
- Gene Names:
- FST
- Gene Names Primary:
- FST
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 344
- Sequence:
- MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
- Gene Ontology Go:
- extracellular region
activin binding
signal transducer activity
hematopoietic progenitor cell differentiation
negative regulation of activin receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
positive regulation of hair follicle development
signal transduction - Gene Ontology Biological Process:
- hematopoietic progenitor cell differentiation
negative regulation of activin receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
positive regulation of hair follicle development
signal transduction - Gene Ontology Molecular Function:
- activin binding
signal transducer activity - Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- P03950; Q14689